The relation of appearance of contrast-enhanced ultrasonography to Ki-67 and C-erbB-2 in breast invasive ductal carcinoma and ductal carcinoma in situ
10.3760/cma.j.issn.1004-4477.2014.12.015
- VernacularTitle:乳腺浸润性导管癌与导管内癌Ki-67、C-erbB-2表达与超声造影表现的关系
- Author:
Zhenyu CAI
;
Lei YAO
;
Jing WANG
;
Baohua WANG
;
Tianan JIANG
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Microbubbles;
Breast neoplasms;
Ki-67 antigen;
Genes,C-erbB-2
- From:
Chinese Journal of Ultrasonography
2014;23(12):1061-1064
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relation of appearance of contrast-enhanced ultrasonography (CEUS) to Ki 67 and C-erbB-2 in breast invasive ductal carcinoma and ductal carcinoma in situ.Methods The appearance of CEUS in 29 patients with breast invasive ductal carcinoma and 12 patients with ductal carcinoma in situ,which was diagnosed by surgery or biopsy,was analysed retrospectively.The Ki-67 and CerbB-2 were measured by immunohistochemical test.The relation of the above two factors to appearance of contrast ultrasonography was analysed.Results The positive rate of Ki-67 was 68.97％ (20/29) in patients with breast invasive ductal carcinoma and 16.67％ (2/12) in patients with ductal carcinoma in situ.The positive rate of C-erbB-2 was 48.2％ (14/29) in patients with breast invasive ductal carcinoma and 42.6％ (5/12) in patients with ductal carcinoma in situ.The masses had a common appearance of high enhance in patients with breast invasive ductal carcinoma and ductal carcinoma in situ,which was not correlated to C-erbB-2.The Ki-67 was significantly higher in patients with ductal carcinoma in situ than that in patients with breast invasive ductal carcinoma,the appearance of CEUS was correlated to Ki 67.Conclusions The features of micro-vessels by CEUS were correlated to Ki-67 in patients with breast invasive ductal carcinoma and ductal carcinoma in situ.
