Relationship between aoiponectin receptor 1 gene + 10225C/G variant and type 2 diabetes
10.3760/cma.j.issn.1008-6706.2015.01.006
- VernacularTitle:脂联素受体1基因+10225C/G多态位点与2型糖尿病的关系
- Author:
Lili ZHANG
;
Xiaoqian ZHANG
- Publication Type:Journal Article
- Keywords:
Receptors,Adiponectin;
Polymorphism,Single Nucleotide;
Diabetes Mellitus,Type 2
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;22(1):17-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between single nucleotide polymorphism (SNP) at position + 10225 in adiponectin receptor 1 gene and type 2 diabetes.Methods The genotypes of + 10225C/G of adiponectin receptor 1 were detected by polymerase chain reaction with sequence specific primers (PCR-SSP) in 200 type 2 diabetes and 100 health controls.Fasting blood samples of all cases were obtained to extract DNA and detect genotype.Statistical software spss 13.0 was used to analyzed.Results Frequency of G-type allele in type 2 diabetes was 40.5％,that in normal controls was 23.5％,there was significant diffierences in the genotype frequencies of SNP+10225 between type 2 diabetes and health controls (x2 =128.0,P＜0.01).Conclusion AdipoR1 + 10225C/G polymorphism was probably associated with type 2 diabetes,G-type allele might be a genetic risk factor of type 2 diabetes.
