Expressions of HIF-1αand CTGF proteins in oral submucous fibrosis

VernacularTitle:口腔黏膜下纤维化中 HIF－1α、CTGF 的表达研究
Author: Lin LIN ; Tianyou LING
Publication Type:Journal Article
Keywords: Oral submucous fibrosis/ME; Hypoxia-inducible factor 1/BI; Immediate-early pro-teins/BI; Intercellular signaling peptides and proteins/BI
From: Journal of Chinese Physician 2015;(3):403-405
CountryChina
Language:Chinese
Abstract: Objective To evaluate the effects of hypoxia inducible factor-1 alpha ( HIF-1α) and connective tissue growth factor (CTGF) proteins in the pathogenesis of oral submucous fibrosis (OSF). Methods Expressions of HIF-1αand CTGF proteins in 30 cases of OSF, and 5 cases of normale control o-ral mucosa tissue were studied with streptomyces peroxidase ( SP) immunohistochemistry with the HIF-1αand CTGF rabbit anti-human polyclonal antibodies.Results The negative expressions of HIF-1αand CT-GF proteins were found in normal control and significant increase was found in OSF ( P <0.05).Conclu-sions HIF-1αand CTGF proteins have positive expression in OSF, both of them may act as an important role in pathogenesis of OSF.