Expression of CCRK in small cell lung cancer and its clinical significance

VernacularTitle:小细胞肺癌组织细胞周期相关激酶的表达及其临床意义
Author: Zewei SHAO ; Fenglian SHAN ; Weiwei SUN ; Leisheng LI ; Shangdan NIE ; Xiaoxia ZHANG ; Hong ZHENG ; Qisen GUO
Publication Type:Journal Article
Keywords: Lung neoplasms/ME; Cyclin-dependent kinases/ME
From: Journal of Chinese Physician 2015;(3):343-346
CountryChina
Language:Chinese
Abstract: Objective To investigate the pathogenesis of small cell lung cancer ( SCLC) and to ex-plore the expression of cell cycle related kinase ( CCRK) in SCLC and its clinical significance.Methods Reverse transcription polymerase chain reaction ( RT-PCR) and Western blot were performed to examine ex-pression of CCRK in SCLC and normal tissues.Results The expressions of gene [(0.51 ±0.11)IU/L] and protein [(0.61 ±0.13)IU/L] of CCRK in SCLC tissues were significantly higher than normal tissues [(0.30 ±0.08)IU/L, (0.34 ±0.09)IU/L] ( P <0.05).The expression of CCRK was closely correlated with the clinical curative effect ( P <0.05 ) rather than the clinical stages ( P >0.05 ) .Conclusions The expressions of gene and protein of CCRK in SCLC tissues were significantly higher than normal tissues. CCRK promoted the occurrence and progress of SCLC.Chem can restrain effectually the excessive expres-sion of CCRK.The expressions of gene and protein of CCRK in the different clinical curative effect group had significant difference.