Bronchiolitis obliterans in children
10.3760/cma.j.issn.1673-4408.2014.06.019
- VernacularTitle:儿童闭塞性细支气管炎的研究进展
- Author:
Jianqin ZHANG
- Publication Type:Journal Article
- Keywords:
Bronchiolitis;
Obliteran;
Children
- From:
International Journal of Pediatrics
2014;41(6):639-643
- CountryChina
- Language:Chinese
-
Abstract:
Bronchiolitis obliterans (BO) designates a clinical syndrome of chronic airflow obstruction associated with inflammatory changes in the small airways.The presentation of pediatric patients is persistent cough,wheezing and activity intolerance after severe respiratory tract infection.The reasons are as follows:severe respiratory tract infection,heart-lung transplantation,bone marrow transplantation,Stevens-Johnson Syndrome,connective tissue disease,inhalation or ingestion of toxic substances,drug factors and so on.The diagnosis of bronchiolitis obliterans is mainly based on the clinical manifestations,high-resolution CT and pulmonary function test,lung biopsy is the golden standard for diagnosis.The early stage is the key period of clinical treatment,most take the continued use of corticosteroids and bronchodilators,combining with other support treatment.This article reviews the etiology,pathogenesis,pathology,clinical manifestations,laboratory examinations,diagnosis,differential diagnosis and treatment of bronchiolitis obliterans in children.
