Research progress of microRNA in the transformation from myelodysplastic syndromes into acute leukemia

VernacularTitle:骨髓增生异常综合征向急性白血病转化相关微小RNA的研究进展
Author: Lin ZHUANG
Publication Type:Journal Article
Keywords: microRNA; Myelodysplastic syndromes; Acute leukemia
From: Journal of Leukemia & Lymphoma 2014;23(9):569-572
CountryChina
Language:Chinese
Abstract: microRNA (miRNA) is a kind of 18 to 25 nucleotide non coding RNAs,which plays an important role in various ways.The abnormal miRNA expression patterns lead to many diseases of hematopoietic system.Myelodysplasitc syndromes (MDS) comprise a heterogeneous group of disorders characterized by ineffective hematopoiesis,bone marrow dysplasia and variable propensity of transformation to acute myeloid leukemia (AML).20 ％-30 ％ MDS patients may progress to AML.miRNA plays a key role in the develpoment,advance and prognosis of MDS.In this paper,the related miRNAs in the transformation from MDS into AML were reviewed.