Advances in research of ATP-binding cassette transporters in drug resistance mechanisms of intractable epilepsy
10.3760/cma.j.issn.1673-4408.2014.06.018
- VernacularTitle:ATP结合盒式蛋白在难治性癫(痫)耐药性机制的研究进展
- Author:
Shuai FU
- Publication Type:Journal Article
- Keywords:
ATP-Binding cassette transporter;
Intractable epilepsy;
Drug resistance
- From:
International Journal of Pediatrics
2014;41(6):636-639
- CountryChina
- Language:Chinese
-
Abstract:
Epilepsy is one of the common diseases in the nervous system with its complicated pathogenesis still remains unknown.The drug resistance mechanism of intractable epilepsy has always been a key point in the research of neuroscience.A possible cause for the drug resistance is the over expression of efflux drug transporters,e.g.ATP-binding cassette transporters,which may decrease extracellular antiepileptic drugs levels in brains of intractable epilepsy patients.ATP-binding cassette transporters are super family of transporter proteins that require ATP hydrolysis for the transport of substrates across membranes,including P-glycoprotein,multidrug resistance-associated protein,major vault protein and breast cancer resistance associated protein.They are major impediment for the AED successful treatment of many forms of refractory epilepsy in human.This paper reviews the research progress on over-expression of ATP-binding cassette transporters and mechanism of drug resistance in intractable epilepsy.
