The Significance of Changes in Sex Hormones after Lamivudine Antiviral Treatment for Hepatitis B in Male Patients with Compensated Cirrhosis
10.3969/j.issn.0253-9896.2014.02.026
- VernacularTitle:男性肝硬化代偿期患者拉米夫定治疗后性激素的变化
- Author:
Yongping PAN
;
Mengbiao QIU
;
Hongxia MAO
;
Xiaohui FAN
;
Qingjuan SU
;
Shuiyin XIONG
;
Hui GONG
- Publication Type:Journal Article
- Keywords:
hepatitis B;
liver cirrhosis;
Lamivudine;
hormones;
estradiol;
male
- From:
Tianjin Medical Journal
2014;(2):184-186
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of sex hormones after lamivudine antiviral treatment in male hepa-titis B patients with compensated cirrhosis, and the significance of changes thereof. Methods Forty-six male patients with compensated cirrhosis were included in patient group. The patient group was given lamivudine antiviral treatment for 24 weeks. The sex hormone levels were compared between before and after treatment. Patients were divided into two groups (complete response group and incomplete response group) according to their response to the treatment. The sex hormone lev-els were compared between these two groups. Results (1)The level of PRL was significantly decreased, and the levels of T and E2 were significantly increased after lamivudine antiviral treatment in patient group.(2)There were significant differenc-es in levels of PRL, T and E2 between complete response group and incomplete response group. Conclusion (1)The lami-vudine antiviral treatment can improve the dysfunction of sex hormones.(2)There was a relationship between the changes of sex hormones and the responses of antiviral treatment.
