Mitochondrial permeability transition pore and hypoxic-ischemia brain damage in neonates
10.3760/cma.j.issn.1673-4408.2014.06.015
- VernacularTitle:线粒体通道转换孔与新生儿缺血缺氧性脑损伤的研究进展
- Author:
Guoyu JI
- Publication Type:Journal Article
- Keywords:
Mitochondria;
Mitochondrial permeability transition pore;
Neonate;
Hypoxic-ischemia brain injury
- From:
International Journal of Pediatrics
2014;41(6):624-628
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondrial permeability transition pore plays a central role in alterations of mitochondrial structure and function,leading to neuronal injury,which is a nonspecific,voltage dependence of complex channel.Hypoxia-ischemia can affect the function of mitochondria,causing mPTP permeability change and leading to cell death.Hypoxia-ischemia brain injury(HIBI) which is caused by perinatal asphyxia threatens neonatal life and leads to neurological sequelae of severe diseases.And mitochondrial dysfunction plays an important role in HIBI.This paper mainly elaborates the relationship between the mPTP and HIBI.
