Early Response of Cardiopulmonary Exercise Test in Patients with Locally Advanced Non-Small Cell Lung Cancer Treated with Systemic Chemotherapy.
10.4046/trd.2002.53.4.369
- Author:
Kyeong Cheol SHIN
1
;
Jin Hong CHUNG
;
Kwan Ho LEE
Author Information
1. Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea. ghlee@med.yu.ac.kr
- Publication Type:Original Article
- Keywords:
Non-small cell lung cancer;
Maximal oxygen uptake;
Oxygen pulse;
Chemotherapy
- MeSH:
Body Composition;
Carbon Monoxide;
Carcinoma, Non-Small-Cell Lung*;
Diagnosis;
Diffusion;
Drug Therapy*;
Exercise Test*;
Exercise Tolerance;
Humans;
Lung;
Lung Neoplasms;
Oxygen;
Quality of Life
- From:Tuberculosis and Respiratory Diseases
2002;53(4):369-378
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The effects of chemotherapy on pulmonary function are mainly a reduced diffusion capacity and a restrictive ventilatory impairment. Exercise can expose cardiovascular and pulmonary abnormalities not evident at rest. Exercise related cardiopulmonary function is important in patients with malignant disease as a determinant of quality of life. We performed this study to evaluate the changes of body composition and cardiopulmonary exercise performance of patients with locally advanced, non-small cell, lung cancer (NSCLC) before and after chemotherapy. METHODS: We evaluated resting pulmonary function, body composition, physiologic performance status, and cardiopulmonary exercise function in 11 patients with locally advanced NSCLC, at diagnosis and prior to the fourth cycle of chemotherapy. RESULTS: After chemotherapy, 4 patients (36.4%) showed partial response and 7 (63.4%) had stable disease. After chemotherapy, diffusion capacity of the lung for carbon monoxide was reduced (89.7+/-34.1%, vs. 71.9+/-20.5%) but not significantly. There were no significant changes in body composition or the state of physiologic performance after chemotherapy. There was a significant impairment of cardiopulmonary exercise tolerance in patients with NSCLC, evidenced by a reduction of maximal oxygen uptake (VO2max, ml/kg/min, 17.9+/-2.6 : 12.6+/-6.1, <0.05) and O2 pulse (O2 pulse, ml/beat, 7.0+/-1.7, 5.2+/-2.1, <0.05). CONCLUSION: Systemic chemotherapy resulted in a loss of cardiopulmonary exercise function in patients with locally advanced NSCLC within the short-term period, but not a physiologic change of body composition within the same period.
