Roles of regulatory T cells and Th17 cells in pathogenesis of Henoch-Schonlein purpura nephritis in children
10.3760/cma.j.issn.1673-4408.2014.06.003
- VernacularTitle:调节性T细胞和Th17细胞在紫癜性肾炎发病机制中的作用
- Author:
Qianqian LIU
;
Yuhong LI
- Publication Type:Journal Article
- Keywords:
Henoch-Schonlein purpura nephritis;
Children;
Th17;
Regulatory T cell
- From:
International Journal of Pediatrics
2014;41(6):581-584
- CountryChina
- Language:Chinese
-
Abstract:
Henoch-schonlein purpura nephritis (HSPN)is the most common pediatric secondary renal glomerular disease.It could play an important role in the pathogenesis and progression of HSPN that regulatory T cells decline in the children and that the differentiation of Th17 cells are maybe not able to be effectively inhibited,leading to the insufficient immunosuppressive effect and the Th17 cells overexpression.We could further study the correlation among HPSN and the quantity and functional imbalance of Th17 cells and regulatory T cells to provide more theoretical basis for clinical treatment of HSPN.
