Progress of Toll-like receptors and the pathogenesis of IgA nephropathy
10.3760/cma.j.issn.1673-4408.2014.06.002
- VernacularTitle:Toll样受体与IgA肾病发病机制的研究进展
- Author:
Yun WANG
- Publication Type:Journal Article
- Keywords:
Toll-like receptor;
Immunoglobulin A nephropathy;
Immune pathogenesis
- From:
International Journal of Pediatrics
2014;41(6):577-580
- CountryChina
- Language:Chinese
-
Abstract:
Immunoglobulin A nephropathy (IgAN),characterized pathologically by deposition of IgA complexes in the glomerular mesangium,is the most common form of primary glomerulo-nephritis in children and adolescents and is considered to be one of the important cause of end-stage renal failure.Abnormal immune factors become the research hotspot in recent years,but the specific pathogenesis has not yet been fully elucidated.Toll-like receptors are a family of receptors,which have been evolutionarily conserved to recognize pathogen-associated molecular patterns.Toll-like receptors do not only play an important role in activation of innate immune,but also regulate acquired immune,which is a bridge connecting the natural immune and acquired immune.Studies have shown that Toll-like receptors plays an important role in the process of occurrence and development of IgAN.This paper reviews its biological characteristics and the pathogenesis of IgA nephropathy.
