Diagnostic and therapeutic advances in relapsed and refractory acute myeloid leukemia

VernacularTitle:复发难治性急性髓系白血病诊疗进展
Author: Meng CHEN ; Li ZHANG ; Ling PAN
Publication Type:Journal Article
Keywords: Leukemia,myeloid,acute; Relapse; Refractory; Diagnosis; Therapy
From: Journal of Leukemia & Lymphoma 2013;22(9):524-527
CountryChina
Language:Chinese
Abstract: Although globally recommended standardized stratification treatment of acute myeloid leukemia (AML) effectively improves its therapeutic effects and prognosis,due to unknown personalized differences of tumorous biology,most of the patients eventually develop to therapy failure,relapse,and even death.Additionally,a number of patients are naturally resistant to current used combined chemotherapy and with extremely poor prognosis,This review presents definitions of refractory and relapsed AML,then describes their pathogenetic mechanism and lastly summarizes three aspects of therapeutic principle,clinical drugs and hematopoietic stem cell transplantation (HSCT).To review advances in relapsed and refractory AML diagnosis and treatment will be helpful to master disease characteristics and to guide clinical treatment.