PET-CT evaluate the response to treatment in patients with multiple myeloma
10.3760/cma.j.issn.1009-9921.2013.08.009
- VernacularTitle:PET-CT在多发性骨髓瘤疗效评估中的作用
- Author:
Qin HUANG
;
Xiaoyan ZHANG
;
Xiaofeng YANG
;
Xiaomin WANG
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Positron emission tomography-computed tomography;
Treatment response
- From:
Journal of Leukemia & Lymphoma
2013;22(8):480-482
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of PET-CT in evaluating the response to the treatment in patients with multiple myeloma.Methods 55 newly diagnosed multiple myeloma patients were collected.Patients were provided with 3 CTD chemotherapy,complete blood examination before and after treatment,parallel PET-CT,and measuring the spine,pelvis,rib SUVmax,each with an average of the SUVmax.The curative effect observated in SUV changes and disease were evaluated.Results In 24 patients after treatment,CR,SUV values were significantly decreased [(3.82±0.83) vs (2.05±0.49),t=9.045,P ＜ 0.001].11 cases of VGPR,SUV values were decreased [(4.77±1.13) vs (3.29±0.49),t =3.998,P =0.001].9 cases of PR,SUV values were slightly decreased [(5.36±0.47) vs (4.97±0.40),t =1.886,P ＞ 0.05],in 8 cases of SD,the SUV values had no obvious change [(6.40±0.96) vs (5.63±0.69),t =1.819,P ＞ 0.05],in 3 cases of disease progression we had higher SUV values from the previous [(6.57±0.72) vs (7.53±4.69),t =-0.353,P ＞ 0.05].CR of 24 cases were followed up for 12 months,SUV values were still high in patients after treatment of the short progression-free survival (PFS) (Some patients only lasted 4 months).Conclusion PET-CT has important value in the evaluation of therapeutic effect of multiple myeloma,it helps to determine the early clinical efficacy,and to plan individualized treatment.
