Alterations of plasmacytoid dendritic cells in peripheral blood of patients with primary Sj?gren′s syn-drome and their significance
10.3760/cma.j.issn.0254-5101.2015.02.007
- VernacularTitle:原发性干燥综合征患者外周血浆细胞样树突状细胞变化
- Publication Type:Journal Article
- Keywords:
Primary Sj?gren′s syndrome;
Plasmacytoid dendritic cells;
TNF-α;
IFN-α;
IL-6
- From:Chinese Journal of Microbiology and Immunology
2015;(2):117-120
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the alterations of plasmacytoid dendritic cells ( pDC) in pa-tients with primary Sj?gren′s syndrome ( pSS) and their significance.Methods Peripheral blood samples were collected from 39 patients with pSS and 15 healthy subjects.The percentages of pDC ( Lin-CD123+HLA-DR+) in peripheral blood samples were analyzed by flow cytometry.The levels of IFN-α, TNF-αand IL-6 in serum samples were detected by ELISA.Results The percentages of pDC in patients with pSS were lower than those in healthy subjects (P<0.05).Higher levels of pDC were detected in patients positive for anti-Sj?gren syndrome antigen A ( anti-SSA) antibody as compared with those in patients negative for anti-SSA antibody.The levels of TNF-αand IL-6 in serum samples from patients with pSS were higher than those in healthy subjects.Conclusion Patients with pSS showed decreased percentages of pDC population, but increased levels of TNF-αand IL-6.The changes of pDC population, TNF-αand IL-6 in peripheral blood might play active roles in the pathogenesis of pSS.
