Role of gonadotropin-releasing hormone on advancing rat puberty onset induced by estradiol

VernacularTitle:促性腺激素释放激素在雌二醇诱导的大鼠青春期启动提前中的作用
Author: Chenfeng HUA ; Rong YANG ; Yuxin LLU ; Lina HUANG ; Li ZHANG ; Tianguang ZHANG ; Dongdong TLAN ; Jun ZHAO ; Zengming ZHAO ; Yimei WANG ; Shuangqing PENG
Publication Type:Journal Article
Keywords: estradiol; puberty; precocious; gonadotropin-releasing hormone
From: Chinese Journal of Pharmacology and Toxicology 2015;(2):260-264
CountryChina
Language:Chinese
Abstract: OBJECTIVE To investigate the role of gonadotropin-releasing hormone (GnRH) in es-tradiol(E2 ) induced advance of puberty onset in rats. METHODS Postnatal day 18 SD rats were given a daily intragastric administration of corn oil or E2(50 μg.kg-1 ) for consecutive 5 d. The day of vaginal opening (VO), pathological changes in ovary and protein expression levels of GnRH, G protein-coupled receptor 54 ( GPR54) and phospholipase C ( PLC) in hypothalamus were observed. RESULTS As compared to corn oil controll group, VO was advanced by about 12.2 d, corpus luteum was observed in the ovary section, and the protein expression levels of GnRH,GPR54 and PLC in hypothalamus were significantly increased by 47%, 55% and 56% in E2 group, respectively. CONCLUSION E2 induced onset of puberty advance may be closely related to regulation of the expression of GnRH, GPR54 and PLC in hypothalamus.