Study of clinicopathologic features of primary mediastinal B-cell lymphoma
10.3760/cma.j.issn.1009-9921.2012.12.006
- VernacularTitle:原发纵隔大B细胞淋巴瘤临床病理学研究
- Author:
Yang HU
;
Min LI
;
Cuiling LIU
;
Xiaoyan WANG
;
Zifen GAO
- Publication Type:Journal Article
- Keywords:
Lymphoma,large B-cell;
Mediastinal neoplasms;
Biological markers;
Pathology,clinical
- From:
Journal of Leukemia & Lymphoma
2012;21(12):720-722
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate clinical pathological features of primary mediastinal B-cell lymphoma (PMBL) and its difference compared with diffuse large B-cell lymphoma,not otherwise specified (DLBCL,NOS).Methods The clinical histories and pathological datas of 24 PMBL cases and 31 cases of DLBCL,NOS as the control group were collected.Immunohistochemical staining and a follow-up study was conducted.Results The distribution of gender showed significant difference when the age of onset of PMBL patients was obviously younger with the medial age of 30 years old (P ＜ 0.001).All cases presented as a huge mass in mediastinal site with compression symptoms.PMBL was similar to DLBCL in the morphology of tumor cells but fibrosis of various degrees was common,more than 70.8 ％ (17/24) cases had the collagen bundles split.CD23 positive rate (40.0 ％,6/15) in PMBL was significantly higher than the control group (3.2 ％,1/31)(P =0.003).Conclusion PMBL frequently occurs in young female people,mostly happens in mediastinal site and adjacent area,but rarely has distant dissemination.PMBL has the characteristics of various degrees of collagen fiber hyperplasia,and CD23 positive could be used to differentiate PMBL from DLBCL,NOS.
