Research progress on microRNAs in the regulation of lymphoma apoptosis

VernacularTitle:微小RNA在淋巴瘤凋亡调控中的研究进展
Author: Zhen JIN
Publication Type:Journal Article
Keywords: Lymphoma; microRNA; Apoptosis
From: Journal of Leukemia & Lymphoma 2012;21(11):700-703
CountryChina
Language:Chinese
Abstract: microRNAs are a class of highly conserved small non-coding RNAs with single-strand,which regulate their target mRNAs at post-transcriptional level.They have been shown to play an important role in the regulation of development of hemopoietic system malignancies.Evading apoptosis is a hallmark of tumorigenesis.In recent years,accumulative data have proved that aberrant expression of microRNAs participates in the regulation of many crucial pathways of apoptosis.By binding to their target mRNAs,microRNAs may inhibit apoptosis (e.g.miR-17-92 cluster,miR-21) or promote apoptosis (e.g.miR-15a/16-1,miR-150),which act as oncogene or tumor suppressor.In addition,the differential expression of microRNAs in lymphoma may provide new markers in determination of prognostic factors.Moreover,insights into microRNA expression in lymphoma may reveal potentially novel therapeutic targets.