Research on the relationship between disease composite index and the prognosis of allogeneic hematopoietic stem cell transplantation
10.3760/cma.j.issn.1009-9921.2013.06.014
- VernacularTitle:疾病综合预后指数与异基因造血干细胞移植预后关系的研究
- Author:
Ying WANG
;
Ling WANG
;
Wei TANG
;
Hanbo DOU
;
Xing FAN
;
Jiong HU
- Publication Type:Journal Article
- Keywords:
Hematopoietic stem cell transplantation,allogeneic;
Composite index;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2013;22(6):365-369
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the impact of a composite index which combines the prognosis of specific hematologic malignancies and the disease remission state pre-transplant on the efficacy of allogeneic hematopoietic stem cell transplantation.Methods A total of 148 patients who underwent allogeneic hematopoietic stem cell transplantation from Jan,2007 to Feb,2012 in the Blood and Marrow Transplantation Center of Ruijin Hospital were included in this retrospective analysis.According to the composite score,patients were classified into low-risk group (n =17),medium-risk group (n =100) and high-risk group (n =31).The overall survival (OS),event free survival (EFS),treatment related mortality (TRM) and relapse rate (RR) were analyzed.Results Significant difference had been found on OS (76.5 ％ vs 66.0 ％ vs 41.9 ％,P =0.002),EFS (70.6 ％ vs 57.0 ％ vs 32.3 ％,P =0.001) and RR (41.9 ％ vs 27.0 ％ vs 5.9 ％,P ＜ 0.001) among the three groups.However,there was no impact on treatment related mortality (23.5 ％,17.0 ％,29.0 ％,P =0.190).Multivariate analysis suggested that the composite index affecting the OS,EFS and RR of allogeneic hematopoietic stem cell transplantation (P =0.005,P =0.001,P ＜ 0.001),but not the TRM (P =0.666).To some extent,it was an independent prognosis index on RR.Conclusion The composite index is closely related to the efficacy of allogeneic hematopoietic stem cell transplantation.
