Lectin-like oxidized low-density lipoprotein receptor-1 and atherosclerosis
10.3760/cma.j.issn.1673-4165.2015.02.014
- VernacularTitle:植物凝集素样氧化型低密度脂蛋白受体-1与动脉粥样硬化
- Author:
Yande ZHOU
;
Yanlin ZHANG
;
Ying XIE
;
Chunfeng LIU
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
ScavengerReceptors,ClassE;
Lipoproteins,LDL;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2015;(2):145-150
- CountryChina
- Language:Chinese
-
Abstract:
Lectin-likeoxidizedLDLreceptor-1(LOX-1)isoneofthemajorreceptorsoftheoxidized low-density lipoproteins (oxLDL). Recent research suggests that LOX-1 can not only bind, neutralize and degrade oxLDL, but also bind some non-oxidized lipoproteins and apoptotic blood cel s. LOX-1 is involved in the process of atherosclerosis through a variety of w ays, such as activating platelet, inducing inflammatory reaction, promoting the proliferation and migration of vascular smooth muscle cels. This article reviews the related research progress from the relationship betw een the structure and function of the LOX-1 and its lipid metabolism and the pathogenesis of atherosclerosis.
