A Randomized,Multi-center and Parallel Control Clinical Trial for Acidic Fibroblast Growth Factor in the Treatment of Deep Second Degree Burn
- VernacularTitle:酸性成纤维细胞生长因子治疗深Ⅱ度烧伤的多中心随机对照临床试验
- Author:
Jiake CHAI
;
Yonghua SUN
;
Zhaofan XIA
;
Zhenjiang LIAO
;
Huade CHEN
;
Chuanan SHEN
;
Shichu XIAO
;
Zhiyong WANG
;
Xiaohua HU
- Publication Type:Journal Article
- Keywords:
Deep second degree burn;
Acidic fibroblast growth factor;
Basic fibroblast growth factor
- From:
China Pharmacist
2015;(4):589-591
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of recombinant human acidic fibroblast growth factor( rh-aFGF)and re-combinant human basic fibroblast growth factor( rh-bFGF)in the treatment of deep second degree burn. Methods:A multicenter,pro-spective,randomized and double-blind clinical trial was conducted. Totally 216 cases of deep second degree burn were selected from five research centers and given appropriate antibiotics and nutritional supplement therapy. The wound of 108 cases in the observation group were rinsing with rh-aFGF(one bottle / 5cm2)according to the wound area at the time of admission followed by rh-aFGF daily spraying,3-4 press/cm2 ,6-8 times a day. The 108 patients in the control group were treated with rh-bFGF with the same regimen as the observation group. After the 30-day follow-up,the wound healing was evaluated in the two groups. Results:The complete healing time,debridement time,complete healing rate in 12 days and 15 days in the observation group were all better than those in the control group(P<0. 05). After the 7-day treatment,the level of leukocyte and seepage score of the observation group were both lower than those of the control group(P<0. 01). The moderate rate showed significant difference between the two groups(P<0. 05). Conclu-sion:rh-aFGF shows better clinical efficacy than rh-bFGF in the treatment of deep second degree burn with the similar safety.
