Study Progress in Eye Irritation Test in vivo for Ophthalmic Preparations
- VernacularTitle:眼用制剂刺激性体内评价方法研究进展
- Author:
Jiayu XIN
;
Hongyu JI
;
Jingling TANG
;
Meng BU
;
Hongmei LIU
;
Linhua WU
- Publication Type:Journal Article
- Keywords:
Ophthalmic formulations;
Eye irritation test;
In vivo;
Joint evaluation
- From:
China Pharmacist
2015;(4):644-646
- CountryChina
- Language:Chinese
-
Abstract:
Various new ophthalmic formulations have been prepared to enhance ocular bioavailability,while lots of irritant sub-stances are applied,including surfactants,polymers and other cationic materials. Therefore,safety of the preparations has been paid more and more attention besides the efficacy. Since in vitro experiments lack of associated enzymes and integral reaction of organiza-tion,the reasonability and correlation of the results extrapolated to the animal experiments still need to be further proved. The in vivo common eye irritation methods( winking,histopathological slices,Draize score and confocal microscopy test etc)were reviewed,eval-uated and analyzed in the paper.
