Study of dynamic changes of peripheral blood D-dimer,IL-6 and Fibrinogen of patients with ovarian cancer

VernacularTitle:卵巢癌患者外周血D－二聚体、FIB水平与IL－6动态变化的研究
Author: Cuihong GAO ; Qingshuang GAO ; Lihong PENG
Publication Type:Journal Article
Keywords: Fibrinogen; IL-6; D-dimer; Ovarian cancer
From: Chinese Journal of Immunology 2015;(4):534-536
CountryChina
Language:Chinese
Abstract: Objective:To determine the level of FIB,IL-6,D-dimer and explore the differential diagnostic value and clinical significance of the tumor markers in patients with ovarian cancers.Methods: The level in serum of 65 ovarian cancer and 35 benign tumor of ovarian and 30 controls FIB and D-dimer were measured by latex agglutination assay.The IL-6 levels were measured by ELISA method.Results:Compared with the normal controls and benign tumor of ovarian cancer, there were some significantly changes in ovarian cancer patients including FIB,IL-6,D-dimer increased (P<0.05),there was no significant differences in FIB,D-dimer levels between ovarian benign tumors and normal controls(P>0.05).Companied with TNM stage increased,the levels of FIB,IL-6,D-dimer ovarian cancer groups increased.The correlation analysis showed that FIB was positively correlated with D-dimer and IL-6 (r=0.56,r=0.31).Conclusion:The level of serum FIB,D-dimer,IL-6 detection in patients with ovarian cancer are helpful in early diagnosis, dicision of clinical stages and regimen prognosis.