Value of Prostate-Specific Antigen, Total Prostate Volume, Transition Zone Volume and Transition Zone Index as the Predictors of Effective Response for Alpha-blocker (Terazosin) Monotherapy in the Management of Benign Prostate Hyperplasia.
- Author:
Sang Hyun PARK
1
;
Luck Hee SUNG
;
Choong Hee NOH
Author Information
1. Department of Urology, Collage of Medicine, Inje University, Sanggye Paik Hospital, Seoul, Korea. urosung@sanggyepaik.ac.kr
- Publication Type:Original Article
- Keywords:
Benign prostatic hyperplasia;
Terazosin monotherapy;
Transition zone volume;
Transition zone index;
PSA
- MeSH:
Humans;
Hyperplasia*;
Male;
Prostate*;
Prostate-Specific Antigen*;
Prostatic Hyperplasia;
Ultrasonography
- From:Korean Journal of Urology
2002;43(10):842-846
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We investigated the efficacy of various parameters by transrectal ultrasonography (TRUS), and PSA levels, as predictors for the effectiveness of alpha-blocker(terazosin) monotherapy. MATERIALS AND METHODS: We evaluated 126 benign prostatic hyperplasic (BPH) patients, who underwent alpha-blocker (terazosin) monotherapy, according to their International Prostate Symptom Score (IPSS), peak flow rate (Qmax), prostate specific antigen(PSA), total prostate volume (TPV), transition zone volume (TZV) and transition zone index (transition zone volume/total prostate volume, TZI) for prediction the response to alpha-blocker (terazosin) monotherapy in men with symptomatic BPH. The patients were categorized into two groups; the good result, and the poor result groups. RESULTS: Following medication with terazosin, the IPSS decreased and the Qmax was significantly increased in all patients. However, according to the patients' subjective satisfaction of the treatment, those in the good result group (64 patients) had smaller TPV and TZV than those in the poor result group (61 patients). There were no significantly differences in PSA and TZI between the two groups. CONCLUSIONS: Terazosin was effective in reducing the symptoms and the improving peak flow rates in symptomatic BPH patients. TPV and TZV correlated significantly with the evaluated parameters in symptomatic BPH patients who underwent alpha-blocker monotherapy.
