Clinical analysis of alveolar hemorrhage in acute leukemia induction therapy and literatures review
10.3760/cma.j.issn.1009-9921.2012.12.012
- VernacularTitle:急性白血病诱导治疗合并肺泡出血的临床分析并文献复习
- Author:
Ran GAO
;
Dali CAI
;
Gang HOU
;
Feng GAO
;
Baixun WANG
;
Jinxiang YU
;
Yan LI
- Publication Type:Journal Article
- Keywords:
Leukemia,acute;
Alveolar hemorrhage;
Induction therapy
- From:
Journal of Leukemia & Lymphoma
2012;21(12):742-745
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical manifestation of diffusive alveolar hemorrhage in acute leukemia induction therapy.Methods Clinical data of two diagnosed cases of diffusive alveolar hemorrhage secondary to acute leukemia were collected.Clinical data of eight cases of diffusive alveolar hemorrhage secondary to acute leukemia which were published were also collected by searching in Medline database.The clinical manifestation,diagnosis,strategy of differential diagnosis and treatment of diffusive alveolar hemorrhage secondary to acute leukemia were analyzed.Results Diffusive alveolar hemorrhage was a rare but fatal complication of acute leukemia.The common clinical manifestations included hemoptysis,progressive dyspnea and progressive decrease in concentration of hemoglobin.The analysis of blood gas showed type Ⅰ respiratory failure.The manifestations of chest computed tomography included diffusive ground glass opacity and infiltration of parenchyma.The bronchoalveolar lavage fluid was bloody.And lung biopsy showed congestion of alveoli and capillaritis.The detection for pathogens,vasculitis related antibodies,brain natrium peptide were negative.The mortality of those cases was 40 ％ (4/10).Corticosteroids therapy was effective.The mortality of patients received corticosteroids therapy was 25 ％ (2/8).Conclusion Diffusive alveolar hemorrhage is a rare but fatal complication of acute leukemia.The mortality is high.The key points of therapy are early diagnosis and corticosteroids therapy.
