Advances on the methods of enhancing the immunological functions of exosomes
10.3760/cma.j.issn.1009-9921.2009.12.021
- VernacularTitle:增强Exosomes免疫功能方法的研究进展
- Author:
Weina REN
;
Chunkang CHANG
;
Huahua FAN
- Publication Type:Journal Article
- Keywords:
Exosomes;
Adjuvants;
immunologic;
Vaccines
- From:
Journal of Leukemia & Lymphoma
2009;18(12):760-763
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are membrane vesicles released into the extracellular environment upon exocytic fusion of multivesicular bodies with the cell surface. As a result of initial studies showing that exosomes display signal and immune factors,a particular interest has emerged in their use as a cellular vehicles for stimulation of immune responses in vivo.In recent years,on the base of the knowledge of the biological properties and functions, exosomes have been rebuilt and bound to different kinds of immunological stimulators as a result to enhanced antitumor funotions.In this paper,the related methods,immunological stimulators and the properties of man-made exosomes are mainly reviewed.
