Comparison of DWI and CT perfusion in diagnosis of liver fibrosis
- VernacularTitle:MR扩散加权成像和CT灌注成像对肝纤维化诊断价值的比较
- Author:
Yue CHENG
;
Wen SHEN
;
Ji QI
- Publication Type:Journal Article
- Keywords:
Liver fibrosis;
Diffusion magnetic resonance imaging;
Tomography,X-ray computed
- From:
Chinese Journal of Medical Imaging Technology
2010;26(2):297-300
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of diffusion weighted imaging (DWI) and CT perfusion imaging (CTPI) in diagnosis of liver fibrosis. Methods Fifty-seven hepatic fibrosis patients and 23 normal controls received DWI (b=500 s/mm2), ADC value of different fibrosis stages was measured, while 35 patients and all 23 normal controls received CTPI. The parameters of CTPI including blood flow (BF), blood volume (BV), mean transit time (MTT), hepatic arterial fraction (HAF) and permeability surface (PS) were measured. Analysis of variances was performed to compare the difference among the groups in both examinations. ROC curve was used to analyze the sensitivity and specificity of DWI and CTPI. Results The difference of ADC value between control group and S1 group was not significant, but between control group and S2, S3, S4 group and among group S2, group S3, group S4 was significant. In the parameters of CTPI, only the difference of HAF between control group and S3-S4 group was significant. Sensitivity and specificity of DWI and CTPI was 78.90%, 82.60% and 66.67%, 73.91%, respectively. Conclusion DWI is superior to CTPI for early diagnosis and degrading of liver fibrosis.
