Expression of Survivin and MMP-9 in Eutopic Endometrium of Patients with Endometriosis
10.3969/j.issn.0253-9896.2010.03.011
- VernacularTitle:Survivin与MMP-9在子宫内膜异位症在位内膜中的表达
- Author:
Shuling MI
;
Jun ZHANG
;
Lirong YIN
;
Hongda MA
;
Xiulan ZHAO
;
Yuquan WANG
- Publication Type:Journal Article
- Keywords:
microtubule-associated proteins;
matrix metalloproteinase 9;
endometriosis;
endometrium;
apoptosis extracellular matrix
- From:
Tianjin Medical Journal
2010;38(3):192-194
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of survivin and MMP-9 in the eutopic endometrium of patients with endometriosis(EMs).Methods:Eighty patients with endometriosis were selected as EMs group,four of them were in clinical stage Ⅰ,25 in stage Ⅱ,44 in stage Ⅲ and 7 in stage Ⅳ,47 in the proliferative phase and 33 in the secretory phase of the menstrual cycles.Twenty patients with hysteromyoma were selected as control group,including 7 patients in the proliferative phase and 13 in the secretory phase of the menstrual cycles.The expression levels of survivin and MMP-9 were determined by immuno-histochemical method.Image-Pro Plus 6.0(IPP),the special-purpose system for quantitative measurement of medical images,was used to analyse the results quantitatively.Results:Both survivin and MMP-9 were found positive in the plasma of the endometriosis.Both survivin and MMP-9 expression levels were higher in EMs group than those in the control group(P ＜0.01).Besides,survivin was over expressed with no relation to the menstrual cycle of the endometium.Survivin expression was higher in endometriosis stage Ⅱ than that of the stage Ⅲ(P ＞ 0.05).There was no difference in survivin expression within other stages(P ＞ 0.05).While MMP-9 expression had no difference between all the endometriosis stages(P ＞ 0.05).There was a close relationship between survivin and MMP-9 expression levels in 80 eutopic endometfium of endometriosis(r=0.262,t=2.860,P ＜ 0.05).Conclusion:The over expression of survivin and MMP-9 may play an important role in the pathogenesis of endometriosis.
