A20 and TNF genes aberration in ocular adnexal MALT lymphomas

VernacularTitle:眼附属器黏膜相关淋巴组织结外边缘区淋巴瘤A20及TNF基因的遗传学改变
Author: Qian NIU ; Qinnuan SUN ; Haiyan LI ; Honggang LIU ; Hongtao YE ; Xiaoge ZHOU ; Zifen GAO ; Liping GONG
Publication Type:Journal Article
Keywords: Lymphoma,B-cell,marginal zone; Eye neoplasms; Genes,A20; Genes,TNF; In situ hybridization,fluorescence
From: Journal of Leukemia & Lymphoma 2012;21(3):141-144
CountryChina
Language:Chinese
Abstract: Objective To investigate the copy number changes of A20 and TNF genes,and determine the contribution of the two genes in the development of ocular adnexal MALT lymphoma.Methods Forty-one cases of archive paraffin-embedded ocular adnexal MALT lymphoma tissues were detected by interphase fluorescence in situ hybridization (FISH) using the commercial chromosome 6 centromere probe (CEP6),and house-made site-specific probe of A20 and TNF. Results Of the 41 ocular adnexal MALT lymphoma cases,loss of heterozygosity (LOH)in A20 locus was detected in 2 cases (4.88 ％).TNF extra copies were found in 5 cases (12.20 ％),of which three cases simultaneously had extra CEP6 signals.No A20 deletion were found coexistence with TNF extra copies in any case.Conclusion A20 gene deletion is present in the small part of ocular adnexal MALT lymphoma, and might contribute to the development of Chinese ocular adnexal MALT lymphoma.A20 deletion is not associated with extra copies of TNF locus.