Study of breast cancer susceptibility gene 1(BRCA1) in common hematologic diseases
10.3760/cma.j.issn.1009-9921.2010.03.019
- VernacularTitle:乳腺癌易感基因与恶性血液病
- Author:
Chunxia MAO
;
Fengru LIN
- Publication Type:Journal Article
- Keywords:
Genes,BRCA1;
Hematologic neoplasms;
Gene expression
- From:
Journal of Leukemia & Lymphoma
2010;19(3):182-184
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, whose encoded proteins play an important role in cell-cycle regulation, DNA damage repair, induction of apoptosis in damaged cells and the maintenance of genomic stability. Some foreign studies reported the down-regulation of BRCA1 expression in initial treatment leukaemia, and this result may have clinical implications for surveillance of therapy and prognosis .In this review, the construction features, biological characteristics of BRCA1 and the expression of BRCA1 in lenkaemia and lymphoma were covered.
