Effect of Acupuncture-moxibustion on TNF-α,sTNFR-Ⅰ and sTNFR-Ⅱ of Rats with C rohn's Disease
10.1007/sll726.009-0029-4
- VernacularTitle:Effect of Acupuncture-moxibustion on TNF-α,sTNFR-Ⅰ and sTNFR-Ⅱ of Rats with C rohn's Disease
- Author:
Zheng SHI
;
Xiaopeng MA
;
Huangan WU
;
Xiudi QIN
;
Qinglan QIAN
;
Wei ZHANG
- Publication Type:Journal Article
- Keywords:
Crohn's Disease;
Acupuncture-moxibustion Therapy;
Tumor Necrosis Factor alpha;
Receptors,Tumor Necrosis Factor,Type Ⅰ;
Receptors,Tumor Necrosis Factor,Type Ⅱ;
Rats
- From:
Journal of Acupuncture and Tuina Science
2009;7(1):29-32
- CountryChina
- Language:Chinese
-
Abstract:
Objeetive:To observe the effect of acupuncture-moxibustion on TNF-a,sTNFR-Ⅰand sTNFR-Ⅱ in rats with Crohn's disease(CD).Method:The models of CD rats induced by TNBS were randomized into model group.herbal cake-partitioned moxibustion group and electroacupuncture group as well as a normal control group.The histopathological changes of colon mucus membrane were observed with HE staining and the contents Of TNF-a.sTNFR-Ⅰand sTNFR-Ⅱ were detected with ELISA method.Results:When compared with the normal group,the TNF-a level in CD rats was substantially elevated and the sTNFR-Ⅰ and sTNFR-Ⅱ showed no marked changes.After herbal cake-partitioned moxibustion and electroacupuncture treatment,the TNF-a level in CD rats was substantially reduced and sTNFRL-Ⅰ and sTNFR-Ⅱ showed no marked changes.The inflammatory lesions and abnormal structures of CD rats were significantly improved after herbal cake-partitioned moxibustion and electric stimulation.Conclusion:Herbal cake-partitioned moxibustion and electroacupuncture Can both remarkably reduce the TNF-a level in blood serum.and this might be one ofthe action mechanisms in the treatment of CD.
