Prevention of Hepatitis B Recurrence After Liver Transplantation:A Randomized Control Investigation
10.3969/j.issn.0253-9896.2010.03.008
- VernacularTitle:肝移植术后预防乙肝复发随机对照研究
- Author:
Tong LIU
;
Jianhua WANG
;
Zhijun ZHU
;
Zhigui ZENG
;
Zhongyang SHEN
- Publication Type:Journal Article
- Keywords:
liver transplantation;
hepatitis B;
recurrence;
protective agents;
immunoglobulins;
randomized controlled trial
- From:
Tianjin Medical Journal
2010;38(3):183-185
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To follow up the hepatitis B recurrence post liver transplantation using the combination of lamivu dine and high-dose intravenous/intramuscular hepatitis B immunoglobulin.Methods:Fifty-two consecutive patients who underwent liver transplantation were included in this analysis.All patients were administered lamivudine combined with hepatitis B immunoglobulin intravenous(V group)or intramuscular(M group)injection prophylaxis.Dosages of hepatitis B immunoglobulin were 4 000 U during anhepatic phase,2 000 U/d during the first six days after operation,2 000 U/week at 2-4 weeks after operation and 2 000 U/month at 2-6 months after operation.The dosages of hepatitis B immunoglobulin were decided by blood concentrations at 6 months after transplantation in both groups(HBsAb titer≥200 U/L during the 6-12 months after operation;100-200 U/L one year after operation).The negative-conversion rates of serum HBsAg,serum HBsAb levels and hepatitis B recurrence rate at the 6th month,1 year after transplantation and at the end of this study were investigated.Results:The daily average negative-conversion rate of serum HBsAg was significantly faster in V group than that of M group within the first 4 postoperative days(P ＜ 0.05).The 100% of serum HBsAg negative-conversion rate was obtained in two groups after one week of operation.No recurrence was found in two groups.And the ease of death was independent on HBV recurrent during the follow-up.Conclusion:Lamivudine combined with hepatitis B immunoglobulin intravenous/intramuscular injection prophylaxis was effective protocol for the hepatitis B recurrence after the liver transplantation.
