Dendritic Cell Functions in Allergen Recognition and Response.
- Author:
Manyong HAN
1
Author Information
1. Department of Pediatrics, College of Medicine, Pochon CHA University, Sungnam, Korea.
- Publication Type:Review
- Keywords:
Dendritic cells;
Antigen presenting cells;
Allergens
- MeSH:
Allergens;
Antigen-Presenting Cells;
Dendritic Cells*;
Inflammation;
Lectins, C-Type;
Toll-Like Receptors
- From:Pediatric Allergy and Respiratory Disease
2005;15(2):87-97
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Dendritic cells (DCs) are crucial in the defense against pathogens and allergen. The ability of allergens to cause allergic inflammation is contingent upon the presence of microenvironment that either privileges Th2 responses or prohibits these reactions. As a simplification, this review tried to prove a causal relationship between a allergic disease and dendritic cell by satisfying the modified Koch's postulates. DCs express C-type lectin receptors (CLRs) and Toll like receptors (TLRs). DCs take up almost all allergen through CLRs. Uptake of allergen by CLRs leads to the production of anti-inflammatory reactions. Although both TLRs and CLRs have distinct functions, the balance between both receptors is instrumental for the immunological outcome.
