A continuous low-dose cyclophosphamide and prednisone regimen for multiple myeloma with severe complications

VernacularTitle:小剂量环磷酰胺联合泼尼松持续应用治疗伴有严重并发症的多发性骨髓瘤
Author: Fan ZHOU ; Jian HOU ; Haotian SHI ; Jianfeng ZOU ; Wei WEI ; Yizi ZHANG ; Shengling YANG
Publication Type:Journal Article
Keywords: Multiple myeloma; Drug therapy,combination; Cyclophosphamide; Prednisone
From: Journal of Leukemia & Lymphoma 2008;17(5):353-355
CountryChina
Language:Chinese
Abstract: Objective To assess the efficacy and tolerability of continuous low-dose cyclophosphamide and prednisone regimen(CP)as salvage therapy for multiple myeloma patients with severe complications.Methods The CP regimen consisted of oral cyclophosphamide at 50 mg and oral prednisone at 15 mg daily.The patients were withdrawn if the response was invalid or not improved after 6 months,and follow-up was carried on if CR maintained for 6 weeks.A total of 23 consecutive patients received the CP regimen,with 18 patients having severe complications,and 5 patients unwilling to accept conventional chemotherapy because of severe infection.All patients had received one to four regimens before.Results Among 23 patients with CP regimen,the overall response rate(CR+VGPR+PR)was 61%,with 1 CR,4 VGPR,9 PR,3 MR and 6 PD.The quality of life and physical conditions were improved significandy.Conclusion Our data showed that CP was an effective,well-tolerated,and convenient regimen as salvage therapy for MM with severe complications.