Correlation between quantitative parameter in power Doppler ultrasonography and angiogenesis of prostate nodules
- VernacularTitle:能量多普勒超声定量参数与前列腺结节血管生成的相关性
- Author:
Qi MA
;
Yuxi SHAN
;
Junchu FANG
;
Dongrong YANG
;
Fang XIE
- Publication Type:Journal Article
- Keywords:
Prostate diseases;
Ultrasonography,Doppler;
Microvessel density
- From:
Chinese Journal of Medical Imaging Technology
2010;26(1):138-141
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the quantitative parameter in transrectal power Doppler ultrasonography (PDUS) and angiogenesis of prostate nodules in pathology. Methods PDUS and the analytic software of color flow were used, and peak vascularization indexs (PVIs) of 94 prostate nodules in 73 patients were recorded. The biopsy specimen was stained with CD34 antibody, and the microvessel density (MVD) was calculated. The correlation between PVI and MVD was statistically analyzed. Results PVI and MVD of the malignant nodules, in both transition zone (TZ) and peripheral zone (PZ), were significantly higher than those of the benign nodules, respectively (P＜0.05). There was positive correlation between PVI and MVD of the malignant nodules (rTZ=0.76;rPZ=0.79), but no correlation between PVI and MVD was found in TZ of benign nodules (r=0.18), while there was correlation between PVI and MVD in PZ (r=0.44). In TZ, the sensitivity and speciality of differentiation malignant nodules from benign nodules were 78.57% and 80.77%, respectively, and in PZ they were 62.07% and 91.00%, respectively. Conclusion As a quantitative parameter in PDUS, PVI can indirectly reflect the angiogenesis of prostate cancerous nodules, providing a new method for differentiation malignant nodules from benign nodules.
