The incidence,natural history, biology, and treatment of transformed lymphomas
10.3760/cma.j.issn.1009-9921.2010.04.001
- VernacularTitle:重视转化型淋巴瘤的生物学特点及诊治策略
- Author:
Huaqing WANG
;
Yun HOU
- Publication Type:Journal Article
- Keywords:
Follicular lymphoma;
Transformation
- From:
Journal of Leukemia & Lymphoma
2010;19(4):193-195
- CountryChina
- Language:Chinese
-
Abstract:
1 or 2 grade FL followed by a diffuse large cell lymphoma(DLCL) ot a Burkitt/Burkitt-like lymphoma is TL.TL maintains a phenotype suggestive of germinal center derivation.The most common immunophenotype is the same as that of FL, CD+10/bcl-6+. Obtaining a biopsy of TL is enhanced if the biopsy is directed to the site with the greatest SUV. The risk of transformation of about 30% at 10 years after the initial diagnosis of FL.The median duration of survival after transformation generally ranging from 1 to 2 years.HDCT-ASCT, allogeneic tranplantation,radioimmunotherapy and bendamustine are the possible therapy for TL.