The incidence,natural history, biology, and treatment of transformed lymphomas

VernacularTitle:重视转化型淋巴瘤的生物学特点及诊治策略
Author: Huaqing WANG ; Yun HOU
Publication Type:Journal Article
Keywords: Follicular lymphoma; Transformation
From: Journal of Leukemia & Lymphoma 2010;19(4):193-195
CountryChina
Language:Chinese
Abstract: 1 or 2 grade FL followed by a diffuse large cell lymphoma(DLCL) ot a Burkitt/Burkitt-like lymphoma is TL.TL maintains a phenotype suggestive of germinal center derivation.The most common immunophenotype is the same as that of FL, CD+10/bcl-6+. Obtaining a biopsy of TL is enhanced if the biopsy is directed to the site with the greatest SUV. The risk of transformation of about 30% at 10 years after the initial diagnosis of FL.The median duration of survival after transformation generally ranging from 1 to 2 years.HDCT-ASCT, allogeneic tranplantation,radioimmunotherapy and bendamustine are the possible therapy for TL.