Prognostic significance of the marrow blast decline index in AML (not APL) at the first inductive treatment for 7-10 days

VernacularTitle:初次诱导治疗七至十天骨髓白血病细胞下降指数与急性髓系白血病预后的关系
Author: Mengxian GUO ; Junmin LI
Publication Type:Journal Article
Keywords: Leukemia; myeloeytic; acute; Prognosis
From: Journal of Leukemia & Lymphoma 2009;18(12):742-743
CountryChina
Language:Chinese
Abstract: Objective To investigate relationship of the marrow blast decline index(MBDI)in AML (not APL)at the first inductive treatment for 7-10 days and the prognosis.Methods 109 cases of AML were retrospectively analyzed(not APL),to compare theⅡmarrow blast decline index in AML(not APL)at the first inductive treatment for 7-10 days in the continue relieve group,the relapse group and the non-remission group,analyzed the correlation of the MBDI and continue relapse rate,the MBDI and relapse rate.Results The MBDI mean value is 0.8856 in continue relieve group.significantly higher than that of the relapse group (mean=0.4445)and the non-remission group(mean=0.3903)(P<0.0001).The MBDl positively correlated with continue relapse rate(P<0.01);negatively correlated with relapse rate(P<0.01).Conclusion The marrow blast decline index in AML(not APL) at the first inductive treatment for 7-10 days was significant for early assesment ofthe prognosis.