Default-mode network in patients with minimal hepatic encephalopathy
- VernacularTitle:轻微型肝性脑病患者静息状态下脑缺省模式网络
- Author:
Rongfeng QI
;
Longjiang ZHANG
;
Zhiqiang ZHANG
;
Yuan ZHONG
;
Zongjun ZHANG
;
Guangming LU
- Publication Type:Journal Article
- Keywords:
Hepatic encephalopathy;
Magnetic resonance imaging;
Default-mode network
- From:
Chinese Journal of Medical Imaging Technology
2010;26(1):47-50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the alteration of the default-mode network (DMN) in the patients with minimal hepatic encephalopathy (MHE) using resting functional MRI, and to explore its underlying clinical significance. Methods Fourteen MHE patients and 14 age-matched normal controls underwent standard resting state functional MRI scan. The components representing DMN were picked out after separation of independent component analysis. One and two sample t-tests were used to observe the changes of DMN in the patients in contrast to the controls. Results Typically spatial distributions of the DMN were found in both MHE patients and controls. Comparison results revealed that there was significantly reduced functional connectivity in the left posterior cingulate cortex, bilateral anterior cingulate cortex, bilateral medial prefrontal cortex, left parahippocampal cortex in MHE patients, while functional connectivity increased in the right precuneus. Conclusion Resting state functional MRI can be used to observe DMN changes in MHE patients. In MHE patients, there is reduced DMN activation in the widespread regions, while the activation of right precuneus increases.
