Characteristics of amorphous calcium phosphate in biomedicine
10.3969/j.issn.2095-4344.2014.39.021
- VernacularTitle:无定形磷酸钙应用在生物医学中的特点
- Author:
Chaoshi QIN
;
Gaoke FENG
;
Xuejun JIANG
;
Xiaoyan LI
- Publication Type:Journal Article
- Keywords:
calcium phosphates;
review;
biomedical research
- From:
Chinese Journal of Tissue Engineering Research
2014;(39):6353-6358
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:With good biocompatibility, bioactivity, control able biodegradation rate, amorphous calcium phosphate is considered as a natural reservoir of calcium and phosphorus, which has been widely used in the biomedical field. OBJECTIVE:To review the latest progress of amorphous calcium phosphate in biomedicine based on its clinical application and characteristics. METHODS:A computer-based search of CNKI, Wanfang database and PubMed database from January 1980 to June 2014 was performed for articles relevant to amorphous calcium phosphate materials with the key words of“amorphous calcium phosphate, biomaterials”in Chinese and English. RESULTS AND CONCLUSION:Amorphous calcium phosphate has been widely used in orthodontic care, bone substitutes, drug delivery material and stents, but it is stil in the developmental stage for the special low differentiated cells, cytokines, targeted drug delivery materials and new biodegradable coronary stent. Based on amorphous calcium phosphate, there are various possible treatments for human diseases. But we cannot blindly exaggerate its advantages but outweigh its disadvantages. For example, whether it wil increase the formation of dental calculus during prevention of dental caries? Whether it wil promote its adjacent tissue calcification or hardening? And whether there are risks leading to vascular calcification or hardening? The advantages and disadvantages of amorphous calcium phosphate when used in human are stil needed to carry out a large scale and long-time research.
