Gold nanoparticles in tumor sensitize radiotherapy:how to maximize the effect of gold nanorods?
10.3969/j.issn.2095-4344.2014.39.024
- VernacularTitle:金纳米颗粒在肿瘤放射增敏治疗中的应用：如何最大效应利用金纳米棒？
- Author:
Lei SHEN
;
Bin GAO
;
Kewu HE
- Publication Type:Journal Article
- Keywords:
nanoparticles;
neoplasms;
review
- From:
Chinese Journal of Tissue Engineering Research
2014;(39):6369-6374
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Gold nanorods have unique optical properties, good histocompatibility, easily control ed surface modification, which have a broad application prospect in the field of biology and medicine. OBJECTIVE:To summarize the optical and thermal properties of gold nanoparticles, and to review the mechanism and research advances of gold nanoparticles, especial y gold nanorods in tumor sensitize radiotherapy. METHODS:A computer-based search of PubMed and CNKI databases was undertaken with the keywords of“gold nanoparticles, radiotherapy sensitivity”in English and Chinese, respectively. The included articles were related to nanoparticles used in vitro and in vivo for clinic study as wel as gold nanoparticles-related tumor sensitize radiotherapy. RESULTS AND CONCLUSION:Gold nanoparticles exhibit unique properties of surface plasmon resonance properties. Compared with the traditional spherical gold nanoparticles, gold nanorods are capsule-like gold nanoparticles containing two absorption peaks that are a transverse surface plasmon resonance absorption peak and a longitudinal surface plasmon resonance absorption peak corresponding to the dimensional characteristics of their horizontal axis and vertical axis, respectively. By regulation of the ratio of horizontal axis and vertical axis, we can realize the manipulation of the longitudinal surface plasmon resonance absorption peak location. Thus, the longitudinal surface plasmon resonance absorption peak can be changed from visible region to the near-infrared region which is the most ideal optical transmission through for al of biological tissues. As a kind of novel radiotherapy sensitization agent, gold nanorods have the properties of low toxicity, high efficiency, high yield. Its sensitization effect is not only related to the exposure dose, own concentration and size, surface modified compounds, but also related to the types of radiation and celllines. However, for radiotherapy sensitization of gold nanorods how to avoid the limits of radioactive ray species, choose appropriate trim and maximize the use of gold nanorods stil need a further research.
