The relationship of Slit2 and bone marrow mesenchymal stem cells with the angiogenesis
10.3969/j.issn.2095-4344.2014.37.024
- VernacularTitle:神经迁移蛋白Slit2与骨髓间充质干细胞及血管再生的关系
- Author:
Lai JIANG
;
Jinning ZHANG
;
Yuan CHAI
;
Fuchun LI
;
Yanping QU
;
Xueling MA
- Publication Type:Journal Article
- Keywords:
bone marrow;
mesenchymal stem cells;
extracellular matrix proteins;
angiogenesis inducing agents
- From:
Chinese Journal of Tissue Engineering Research
2014;(37):6034-6039
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Bone marrow mesenchyme stem cells are important non-hematopoietic stem cells in the bone marrow, which can stimulate angiogenesis. While, Slit can also stimulate angiogenesis, as many studies have proved. OBJECTIVE:To review the biological functions, clinical application and effects of bone marrow mesenchymal stem cells and Slit2 on promoting angiogenesis. METHODS:A computer-based online research of CNKI and PubMed databases was performed to col ect articles published between 1980 and 2014 with the keywords“MSCs”and“Slit2”in Chinese and English. There were 436 articles after the initial survey. Final y, 65 articles were included according inclusion and exclusion criteria. RESULTS AND CONCLUSION:Both bone marrow mesenchymal stem cells and Slit2 play an important role in promoting angiogenesis, but the relevance of bone marrow mesenchymal stem cells and Slit2 is stil controversial. If assuming that bone marrow mesenchymal stem cells secrete Slit2, more researches should be done to reveal whether bone marrow mesenchymal stem cells promoting angiogenesis is relevant to Slit2 and through which signaling pathway Slit2/Robo functions to adjust bone marrow mesenchymal stem cells thus to promote angiogenesis. If relevant, the transplantation of the Slit2 and bone marrow mesenchymal stem cells wil be a promising treatment of cerebral infarction and other central nervous injuries.
