Nano-hydroxyapatite/polyamide 66 scaffold and tantalum rod in the treatment of early-stage osteonecrosis of the femoral head:comparison of short-term efficacy
10.3969/j.issn.2095-4344.2014.39.011
- VernacularTitle:纳米羟基磷灰石/聚酰胺66骨支撑材料与钽棒置入修复早期股骨头坏死：近期效果比较
- Author:
Hongyao XU
;
Jianning ZHAO
;
Ting GUO
- Publication Type:Journal Article
- Keywords:
hydroxyapatites;
femoral head necrosis;
nanoparticles
- From:
Chinese Journal of Tissue Engineering Research
2014;(39):6292-6297
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Nano-hydroxyapatite/polyamide 66 has been used in the treatment of early avascular necrosis and obtained the good curative effect that can significantly reduce the pain and delay the col apse of the femoral head. OBJECTIVE:To evaluate the efficacy of core decompression with bone graft and nano-hydroxyapatite/polyamide 66 scaffold implantation versus core decompression with bone graft and tantalum rod implantation in treating early-stage avascular necrosis of the femoral head. METHODS:Total y 60 patients with early femoral head necrosis were randomly divided into two groups:observation group and control group. The observation group was treated by core decompression with bone graft and nano-hydroxyapatite/polyamide 66 scaffold implantation, and the control group treated by core decompression with bone graft and tantalum rod implantation. Then, we compared the time of operation, postoperative drainage volume, hospital stay, hospitalization expense, the number of postoperative pain between two groups. Al the subjects were fol owed for 12 months. The efficacy of two different surgical methods was evaluated by Harris scores, imaging curative effect and comprehensive curative effect. RESULTS AND CONCLUSION:Postoperative drainage volume, hospital stay, and hospital expenses were lower in the observation group than the control group (P<0.05). There were no significant differences in the operation time and the number of postoperative pain between the two groups (P>0.05). In the Harris hip scoring, only walking auxiliary score in the observation group was significantly better than that in the control group (P<0.05). There were no significant differences in the X-ray change and comprehensive efficacy evaluation between the two groups (P>0.05). For patients with early osteonecrosis of the femoral head, core decompression with bone graft and tantalum rod or hydroxyapatitescaffold implantation have similar clinical efficacy.
