Interaction of polymorphisms in resistin gene promoter -420C/G, cyto-chromes P4501 A1 gene MspI and cigarette smoking on nonalcoholic fatty liver disease
10.3969/j.issn.1000-4718.2015.03.018
- VernacularTitle:抵抗素基因启动子－420C／G、细胞色素P4501A1-MspI多态性与吸烟的交互作用对非酒精性脂肪性肝病的影响
- Author:
Chaoxian ZHANG
;
Like GUO
- Publication Type:Journal Article
- Keywords:
Nonalcoholic fatty liver disease;
Resistin gene promoter -420C/G;
Cytochromes P4501A1-MspI;
Genetic polymorphism;
Cigarette smoking
- From:
Chinese Journal of Pathophysiology
2015;(3):485-491
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the interaction of polymorphisms of resistin gene promoter -420C/G, cyto-chromes P4501A1-MspI and cigarette smoking in nonalcoholic fatty liver disease (NAFLD).METHODS: The genetic polymorphisms in resistin gene promoter -420C/G and CYP1A1-MspI were analyzed by the technique of polymerase chain reaction ( PCR) in peripheral blood leukocytes of 900 NAFLD cases and 900 healthy persons.RESULTS:The frequencies of -420C/G (GG) and CYP1A1-MspI (m2/m2) were 49.75%and 50.08%in NAFLD cases and 24.00%and 24.25%in healthy controls, respectively.Statistical tests showed a significant difference in the frequencies between the 2 groups ( P<0.01).The risk of NAFLD with -420C/G (GG) was significantly higher than that of controls.Individuals who carried with CYP1A1-MspI (m2/m2) had a high risk of NAFLD.Combined analysis of the polymorphisms showed that the per-centages of -420C/G (GG)/CYP1A1-MspI (m2/m2) in NAFLD and control groups were 39.83% and 12.83%, re-spectively (P<0.01).The people who carried with -420C/G (GG)/CYP1A1-MspI(m2/m2) had a high risk in NAFLD group.The cigarette smoking rate in NAFLD group was signi-ficantly higher than that in control group ( P<0.01) , and the statistic analysis suggested an interaction between cigarette smoking and -420C/G (GG) and CYP1A1-MspI (m2/m2), which increased the risk of NAFLD.CONCLUSION: -420C/G (GG), CYP1A1-MspI (m2/m2) and cigarette smoking are the risk factors in NAFLD.The interactions between genetic polymorphisms in -420C/G, CYP1A1-MspI ( m2/m2) and cigarette smoking increase the risk of NAFLD.
