Expression of A20 in patients with systemic lupus erythematosus
10.3969/j.issn.1000-4718.2015.03.023
- VernacularTitle:系统性红斑狼疮中 A20表达特点的研究
- Author:
Fan ZHANG
;
Lihua ZHU
;
Xu WANG
;
Shaohua CHEN
;
Lijian YANG
;
Xiuli WU
;
Bo LI
;
Yi ZHOU
;
Yangqiu LI
- Publication Type:Journal Article
- Keywords:
Systemic lupus erythematosus;
A20;
MALT1;
NF-κB
- From:
Chinese Journal of Pathophysiology
2015;(3):518-523
- CountryChina
- Language:Chinese
-
Abstract:
[ ABSTRACT] AIM:To investigate the expression and regulation of A20 in healthy individuals and the patients with systemic lupus erythematosus (SLE).METHODS:The expression levels of A20, NF-κB, MALT1, and MALT1V1 in peripheral blood mononuclear cells ( PBMC) of the patients with SLE ( including 2 cases with scleroderma, 1 case with rheumatoid arthritis, and 1 case with lymphoma) were analyzed by real-time PCR.RESULTS:A significantly lower A20 expression level was found in the PBMC from SLE group compared with the healthy controls, while the expression levels of MALT1 and NF-κB were also decreased.In addition, no significant correlation between A20 and NF-κB expression levels in healthy group was observed, but a positive correlation was found in SLE group ( P<0.05) .A significant positive corre-lation between MALT1 and NF-κB expression levels in healthy group ( P<0.05) was observed, and no significant correla-tion was found in SLE group.The expression level of MALT1V1 in SLE group was significantly lower than that in healthy control group, and there was a positive correlation between A20 and MALT1V1 in healthy volunteers (P<0.01), but that did not exist in SLE group.CONCLUSION: The characteristics of the expression pattern of MALT1-A20-NF-κB in the SLE patients were presented.Lower level of A20 expression was found in the SLE patients, in particular with other autoim-mune disease or lymphomas, indicating the lower immune tolerance in SLE.The positive correlation of A20 and NF-κB may relate to positive regulation of MALT1.
