Cyclooxygenase-2 Expression according to Size and Location of Gastric and Colorectal Tubular Adenomas.
- Author:
Se Hwan KIM
1
;
Jong Hyup LEE
;
Kyung Hee KANG
;
Jee Hyun PARK
;
Chang Keun PARK
;
Chang Min CHO
;
Young Oh KWEON
;
Sung Kook KIM
;
Yong Hwan CHOI
;
Han Ik BAE
;
Mi Sung KIM
Author Information
1. Department of Internal Medicine, Kyungpook National University College of Medicine, Daegu, Korea. durumi88@yahoo.co.kr
- Publication Type:Original Article ; English Abstract
- Keywords:
Cyclooxygenase-2;
Gastric adenoma;
Colorectal adenoma
- MeSH:
Adenoma/enzymology/*pathology;
Aged;
Colorectal Neoplasms/enzymology/*pathology;
English Abstract;
Female;
Humans;
Immunohistochemistry;
Male;
Middle Aged;
Prostaglandin-Endoperoxide Synthase/*analysis;
Stomach Neoplasms/enzymology/*pathology
- From:The Korean Journal of Gastroenterology
2004;44(4):206-211
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Recent studies have shown that cyclooxygenase-2 (COX-2) may be involved in the process of invasion, growth and apoptosis in colorectal carcinoma and in the growth and tumorigenesis in familial adenomatous polyposis. This study was conducted to determine the significance of the expression of COX-2 in gastric and colorectal adenomas. METHODS: Forty-nine samples of gastric adenoma and fifty-seven samples of colorectal adenoma were obtained by endoscopic mucosal resection or polypectomy from 106 patients from January 2000 to July 2003. COX-2 expression was determined by immunohistochemistry. Correlation between COX-2 expression and several clinical factors were compared in each gastric and colorectal adenomas. RESULTS: The expression of COX-2 in epithelial cells was significantly higher in the group with large adenoma (>1 cm) compared with the group with small adenoma (
