Effects of myosin light chain kinase on regulation of endothelial barrier function
10.3969/j.issn.1000-4718.2015.03.034
- VernacularTitle:肌球蛋白轻链激酶介导内皮细胞屏障功能变化的研究进展
- Author:
Jie WU
;
Weijin ZHANG
;
Qiaobing HUANG
- Publication Type:Journal Article
- Keywords:
Myosin light chain kinase;
Myosin;
Endothelial cells;
Permeability
- From:
Chinese Journal of Pathophysiology
2015;(3):572-576
- CountryChina
- Language:Chinese
-
Abstract:
[ ABSTRACT] Myosin light chain kinase ( MLCK) activates the regulatory light chain of myosin II, and the phos-phorylated myosin light chain leads to actomyosin contractile activity, as well as the cell contraction and increasing intercel-lular gap, which finally results in endothelial barrier dysfunction.MLCK-dependent hyperpermeability occurs in response to multiple cell signaling molecules and signaling pathways, including Ca2+, Src, PKC, NO, cGMP and mitogen activated protein kinases ( MAPK) .In this review, different mechanisms of endothelial hyperpermeability mediated by MLCK are discussed.
