The effects of splenectomy plus esophagogastric devascularization on serum MMP-1,TIMP-1 and cirrhotic serum markers of liver cirrhosis patients
10.3969/j.issn.1005-6483.2015.03.016
- VernacularTitle:脾切除贲周血管离断术对肝硬化患者术后血清MMP-1、TIMP-1及肝纤维化指标的影响
- Author:
Jianchun WANG
;
Jian CHEN
;
Xushun LIU
- Publication Type:Journal Article
- Keywords:
splenectomy plus esophagogastric devascularization;
liver cirrhosis;
matrix met-alloproteinase-1;
tissue inhibitor of metalloproteinase-1
- From:
Journal of Clinical Surgery
2015;(3):200-202
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects and their potential mechanisms of splenectomy plus esophagogastric devascularization on non-invasive indexes of liver fibrosis and the cirrhosis progress in portal hypertensive patients with HBV-related cirrhosis. Methods Twenty consecutive portal hypertensive patients with positive HBsAg,negative HBV-DNA and Child-Pugh A(n=14)or B(n=6)were collected in this study. ELISA method was used to test the level of serum MMP-1 and TIMP-1;electrochemilumines-cence was used to measure hyaluronic acid( HA),N-terminal type Ⅲ procollagen peptide( PC-Ⅲ),lami-nin(LN)and collagen typeⅣ(C-IV). Results The serum TIMP-1,HA,PCⅢ,LN,and C-Ⅳwere signifi-cantly lower than the preoperative levels(p<0. 05),and MMP-1 slowly increased compared with the pre-operative levels(p<0. 05). The changes between TIMP-1 and HA,PC-Ⅲ,LN,or C-Ⅳ were positively correlated(r=0. 458~0. 783,p<0. 01/0. 05). The changes between MMP-1 and HA,PC-Ⅲ,LN,or C-Ⅳ were negatively correlated(r= -0. 545~ -0. 873,p<0. 01/0. 05). Conclusion Splenectomy plus esophagogastric devascularization can decrease non-invasive hepatic fibrosis serum markers and cytokines (TIMP-1),conducive to slowing down the disease progression in patients with cirrhosis.
