The expression of miR-451 and its clinical significance in gastric cancer
10.3969/j.issn.0253-9896.2015.03.012
- VernacularTitle:miR-451在胃癌组织中的表达及其临床意义
- Author:
Tao CHEN
;
Liming XIE
;
Hailin TANG
- Publication Type:Journal Article
- Keywords:
stomach neoplasms;
carcinoma;
prognosis;
gene expression;
in situ hybridization;
miR-451
- From:
Tianjin Medical Journal
2015;(3):267-269
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of miR-451 and its clinical significance in gastric cancer. Meth?ods The miR-451 expression was detected in 92 samples of gastric cancer and 47 sapmles of normal stomach mucosa. The correlations of miR-451 expression with clinicopathologic characteristics, overall survival and disease-free survival were an?alyzed in patients with gastric cancer. Results The overexpression rate of miR-451 was 38.04%in gastric cancer, which was significantly lower than 76.60%in adjacent normal tissues (χ2=18.503,P<0.001). The overexpression rate of miR-451 was significantly lower inⅢ-Ⅳstages of gastric cancer than that inⅠ-Ⅱstages (27.3%vs 54.1%, P=0.009). The expres?sion of miR-451 was also lower in patients with lymph node metastasis than that in patients without lymph node metastasis (27.1%vs 57.6%, P=0.004). However, there were no significant differences in miR-451 expressions between different age, gender, histological grade and T stage groups (P>0.05). The overall survival rate was significantly higher in patients with high expression of miR-451 than that in patients with low expression of miR-451(69.2%vs 39.1%, P=0.003). Conclusion miR-451 is associated with the malignant transformation, progression, and prognosis of gastric cancer, and which can be used as a potential target of therapy and a biomarker of diagnosis and prognosis of gastric cancer in the future.
