The expression and significance of MDSCs in peripheral blood in patients with peripheral T cell lymphoma
10.3969/j.issn.0253-9896.2015.03.016
- VernacularTitle:外周T细胞淋巴瘤患者外周血中髓源性抑制细胞的表达及意义
- Author:
Yanli LI
;
Qing BU
- Publication Type:Journal Article
- Keywords:
lymphoma,T-cell,peripheral;
flow cytometry;
myeloid-derived suppressor cells
- From:
Tianjin Medical Journal
2015;(3):282-284
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the number of myeloid-derived suppressor cells (MDSCs) in peripheral blood and prognosis in patients with peripheral T-cell lymphoma (PTCL). Methods Twenty-three patients with PTCL were selected in this study and 14 healthy persons were used as the normal control. The proportion of MDSCs/mononu?clear in peripheral blood was detected by flow cytometry. The correlation between the number of MDSCs and the clinical character and prognosis in patients with PTCL was analyzed. Results The proportion of MDSCs in peripheral blood was sig?nificantly higher in patients with PTCL than that of healthy subjects [(4.59±1.41)%vs (1.36±0.59)%, P<0.01]. The number of MDSCs in peripheral blood was significantly decreased after chemotherapy compared with that before treatment [( 1.29 ± 2.95)%, P<0.05)]. There were significant differences in MDSCs expressions in patients between different extranodal involve?ment, bone marrow involvement, clinical stage and IPI score (P<0.05). Conclusion The higher expression of MDSCs may be related to the progression in patients with PTCL.
