Comparison study of risk factors between premenopausal and postmenopausal female patients with coronary heart disease
10.3969/j.issn.0253-9896.2015.03.019
- VernacularTitle:女性绝经前后冠状动脉粥样硬化性心脏病危险因素的对比研究
- Author:
Bin SU
;
Qin QIN
;
Yang LI
- Publication Type:Journal Article
- Keywords:
coronary disease;
menopause;
premenopause;
postmenopause;
risk factors;
female;
dyslipidemia
- From:
Tianjin Medical Journal
2015;(3):292-295
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore changes of risk factors between premenopausal and postmenopausal female patients with coronary heart disease (CHD). Methods A total of 283 female patients were divided into CHD group (n=154) and con?trol group (n=129) according to whether they suffered from CHD or not. Patients were further stratified into two groups accord?ing to menopausal situation:premenopausal group (n=78, including premenopausal CHD group of 34 cases and premenopaus?al control group of 44 cases) and postmenopausal group (n=205, including postmenopausal CHD group of 120 cases and post?menopausal control group of 85 cases). Clinical data of age, body mass index (BMI), medical history and menses situation were recorded. The levels of cholesterol (CHO), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low density lipo?protein cholesterol (LDL-C), very low density lipoprotein cholesterol (vLDL-C), apolipoprotein AI (ApoAI), apolipoprotein B (apoB), lipoprotein a (Lpa), homocysteine (HCY) and high-sensitive C-reactive protein (hsCRP) were also detected. Results There were significantly higher levels of age, CHO, TG, LDL-C, vLDL-C, Lpa, ApoB, hsCRP, and the ratio of hypertension history, diabetic history, coronary heart disease family history in CHD group than those of control group. The level of HDLc was significantly lower in CHD group than that of control group. The ratio of hypertension history, diabetic history and levels of CHO, TG, LDL-C, vLDL-C, Lpa, ApoB, hsCRP were significantly higher in both premenopausal and postmenopausal CHD groups than those of their control groups. The level of HDL-C was significantly lower in postmenopausal CHD group than that of postmenopausal control group (P<0.05). Hypertension history, diabetic history and LDL-C were the independent risk fac?tors of premenopausal CHD. Hypertension history, diabetic history and CHO were the independent risk factors of postmeno?pausal CHD, and HDL-C was the protecting factor of CHD. The ratio of hypertension history, the level of CHO and LDL-C were significantly higher in postmenopausal CHD group than those of premonopausal CHD group. Conclusion The abnor?mal blood pressure level and dyslipidemia are more prevalent in postmenopausal female patients with CHD than premeno?pausal female patients. We should control these risk factors to improve the prognosis.
